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Oxidative stress and antioxidants
He studies which molecules protect DNA and proteins from free-radical damage, and how fast they act.
He studies how free radicals damage DNA, proteins and lipids, and which molecules can prevent it. Some do so by trapping the radical, and others by chemically repairing damage that has already occurred. He calculates not only whether a molecule can protect, but how fast it does so under physiological conditions, since that determines whether it actually works. He has analyzed melatonin, glutathione, vitamin C and dietary polyphenols. He also designs new antioxidants computationally before they are synthesized.
- oxidative stress